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Head Group Influence on Lipid Interactions With a Polyhydroxyalkanoate Biopolymer


 
 
Contact   Zinn Manfred
 
Title   Head Group Influence on Lipid Interactions With a Polyhydroxyalkanoate Biopolymer
 
Author(s)   Jagoda Agnieszka, Zinn Manfred, Meier Wolfgang, Kita-Tokarczyk Katarzyna
 
References   Macromolecular Chemistry and Physics, 2012, 213 (18), 1922-1932
 
Url   http://dx.doi.org/10.1002/macp.201200232
 
Abstract   Poly([R]-3-hydroxy-10-undecenoate) (PHUE) is a biodegradable/biocompatible polyester from polyhydroxyalkanoates (PHAs) family, used in biomedical applications. PHA's introduction to the body may have implications on cell membrane stability—this motivates studies of interactions between PHAs and phospholipids, main membrane constituents. Interaction analysis in PHUE monolayers with two phospholipids (different hydrophilic groups), phosphatidylserine (DOPS), and phosphatidylethanolamine (DOPE), shows that repulsive interactions between PHUE and DOPS and attractive between PHUE and DOPE resulted from different lipid headgroup size and orientation at the air–water interface (PE, parallel to the interface, attracted PHUE via hydrogen bonds, ion–dipole, and dipole–dipole interactions).
 
 
 
 
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