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| Contact |
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Brück Wolfram |
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| Title |
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Dynamics of infant gut microbiota are influenced by delivery mode and gestational duration and are associated with subsequent adiposity |
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| Author(s) |
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Shaillay Dogra, Olga Sakwinska, Shu-E Soh, Catherine Ngom-Bru, Wolfram M Brück, Bernard Berger, Harald Brüssow, Yung Seng Lee, Fabian Yap, Yap-Seng Chong, Keith M Godfrey, Joanna D Holbrook |
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| References |
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American Society for Microbiology, 2015, 6, 1 |
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| Url |
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http://dx.doi.org/10.1128/mBio.02419-14 |
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| Abstract |
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We found that the relatively simple microbiota of young infants shifts predictably to a more mature anaerobic microbiota during infancy and the dynamics of this shift are influenced by environmental factors. In this longitudinal study of 75 infants, we demonstrate high interindividual variability within the normal range of birth outcomes, especially in the rate of microbiota progression. Most had acquired a microbiota profile high in Bifidobacterium and Collinsella by 6 months of age, but the time point of this acquisition was later in infants delivered by caesarean section and those born after a shorter duration of gestation. Independently of the delivery mode and gestation duration, infants who acquired a profile high in Bifidobacterium and Collinsella at a later age had lower adiposity at 18 months of age. |
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