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| Contact |
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Zinn Manfred |
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| Title |
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Interactions of Biodegradable Poly ([R]-3-hydroxy-10-undecenoate) with 1, 2-Dioleoyl-sn-glycero-3-phosphocholine Lipid: A Monolayer Study |
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Agnieszka Jagoda, Pantelis Ketikidis, Manfred Zinn, Wolfgang Meier, Katarzyna Kita-Tokarczyk |
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| References |
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Langmuir, 2011, 27, 17, 10878-10885 |
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| Url |
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http://dx.doi.org/10.1021/la201654d |
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| Abstract |
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Polyhydroxyalkanoates (PHAs) are biodegradable, biocompatible polyesters and very attractive candidates for biomedical applications as materials for tissue engineering. They have a hydrophobic character, but some are able to spread at the air–water interface to form monomolecularly thin films (Langmuir monolayers). This is a very convenient model to analyze PHA self-assembly in two dimensions and to study their molecular interactions with other amphiphilic compounds, which is very important considering compatibility between biomaterials and cell membranes. We used the Langmuir monolayer technique and Brewster angle microscopy to study the properties of poly([R]-3-hydroxy-10-undecenoate) (PHUE) films on the free water surface in various experimental conditions. Moreover, we investigated the interactions between the polymer and one of the main biomembrane components, 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC). The addition of lipid to a polymer film does not change the monolayer phase behavior; however, the interactions between these two materials are repulsive and fall in two composition-dependent regimes. In summary, this is the first systematic study of the monolayer behavior of PHUE, thus forming a solid basis for a thorough understanding of material interactions, in particular in the context of biomaterials and implants. |
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